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Multiple Myeloma – Symptoms, Diagnosis, Treatment, Mnemonic

Multiple myeloma 

Multiple myeloma (aka Plasma cell myeloma), is an abnormal proliferation of  plasma cells, a type of white blood cell present in the bone marrow. Normal plasma cells are responsible for making antibodies that helps the body fight infections. In multiple myeloma, these plasma cells are unregulated in their production and therefore they make useless antibodies. These antibodies are IgG or IgA which do not fight infections but clog up the kidney.

Sings and symptoms of Multiple Myeloma:

Multiple Myeloma Mnemonic:

Diagnostic Test for Multiple Myeloma:

Other laboratory abnormalities include:

Treatment of Multiple Myeloma:

Initial treatment of multiple myeloma depends on the patient’s age and comorbidities.

Patients over age 65 and patients with significant concurrent illness often cannot tolerate stem cell transplantation. For these patients, the standard of care has been:

 

References:

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