Thrombocytopenia Differential Diagnosis

Thrombocytopenia Differential Diagnosis:

Thrombocytopenia is the medical term for a low blood platelet count. Platelets (thrombocytes) play an important role in blood clotting. Platelets stop blood loss by clumping and forming plugs in blood vessel holes. Thrombocytopenia often occurs as a result of a separate disorder, such as leukemia or an immune system problem, or even due to some medication side effect. It may be mild and cause few signs or symptoms. In rare cases, the number of platelets may be so low that dangerous internal bleeding can occur.


We can divide Thrombocytopenia into two different group of disorders based on their etiology:

1. Bone marrow disorders:

In this group of disorders, thrombocytopenia due to the bone marrow itself and it is not associated with any secondary cause or any other disorders. The main bone marrow disorders are:


2. Non-Bone marrow disorders:

In this group of disorders, thrombocytopenia is due to a secondary cause that eliminate platelets from circulation or may have  an effect on the bone marrow causing it to slow down or stop its production of platelets or .  Some of the secondary causes are:


General symptoms include:


 Diagnostic test and Exams:

Your health care provider will perform a physical exam and ask questions about your medical history and symptoms. The following tests may be done:

Other tests that may help diagnose this condition include:



Thrombocytopenia usually improves when the underlying cause is treated. Sometimes medications, surgery or a blood transfusion can help treat chronic thrombocytopenia.


References: 1, 2


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